Human Pathology
Volume 41, Issue 10 , Pages 1438-1447 , October 2010

Expression of Sox2 in human cervical carcinogenesis

  • Jing Ji, PhD

      Affiliations

    • Department of Reproductive Medicine, the First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an 710061, The People's Republic of China
    • ,
  • Peng-Sheng Zheng, MD, PhD

      Affiliations

    • Department of Reproductive Medicine, the First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an 710061, The People's Republic of China
    • Section of Cancer Stem Cell Research, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of People's Republic of China, Xi'an 710061, The People's Republic of China
    • Corresponding Author InformationCorresponding author. Department of Reproductive Medicine, the First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an 710061, The People's Republic of China.

Received 27 August 2009 ,Revised 12 November 2009 ,Accepted 20 November 2009.

References 

  1. Eiben GL, da Silva DM, Fausch SC, Le Poole IC, Nishimura MI, Kast WM. Cervical cancer vaccines: recent advances in HPV research. Viral Immunol. 2003;16:111–121
  2. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3:730–737
  3. Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003;63:5821–5828
  4. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A. 2003;100:3547–3549
  5. Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells. Nature. 2007;445:111–115
  6. Gu GY, Yuan JL, Wills M, Kasper S. Prostate cancer cells with stem cell characteristics reconstitute the original human Tumor in vivo. Cancer Res. 2007;67:4807–4815
  7. Gangemi RMR, Griffero F, Marubbi D, et al. Sox2 silencing in glioblastoma Tumor initiating cells causes stop of proliferation and loss of tumorigenicity. Stem Cells. 2009;27:40–48
  8. Chiou SH, Yu CC, Huang CY, et al. Positive correlations of Oct4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clin Cancer Res. 2008;14:4085–4095
  9. Sinclair AH, Berta P, Palmer MS, et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature. 1990;346:240–244
  10. Wegner M. From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res. 1999;27:1409–1420
  11. Kamachi Y, Uchikawa M, Kondoh H. Pairing SOX off: with partners in the regulation of embryonic development. Trends Genet. 2000;16:1822–1827
  12. Boer B, Kopp J, Mallanna S, et al. Elevating the levels of Sox2 in embryonal carcinoma cells and embryonic stem cells inhibits the expression of Sox2: Oct-3/4 target genes. Nucleic Acids Res. 2007;35:1773–1786
  13. Chew JL, Loh YH, Zhang W, et al. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol. 2005;25:6031–6046
  14. Gure AO, Stockert E, Scanlan MJ, et al. Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer. Proc Natl Acad Sci U S A. 2000;97:4188–4203
  15. Rodriguez-Pinilla SM, Sarrio D, Moreno-Bueno G, et al. Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer. Mod Pathol. 2007;20:474–481
  16. Sanada Y, Yoshida K, Ohara M, Oeda M, Konishi K, Tsutani Y. Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor Sox2: comparison of expression patterns between invasive components and cancerous or nonneoplastic intraductal components. Pancreas. 2006;32:164–170
  17. Ostubo T, Akiyama Y, Yanagihara K, Yuasa Y. Sox2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. Br J Cancer. 2008;98:824–831
  18. Li AS, Siu MK, Zhang H, et al. Hypermethylation of Sox2 gene is hydatidiform mole and choriocarcinoma. Reprod Sci. 2008;15:735–744
  19. Dontu G, Abdallah WM, Foley JM, et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev. 2003;17:1253–1270
  20. Park ET, Gum JR, Kakar S, Kwon SW, Deng G, Kim YS. Aberrant expression of Sox2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions. Int J Cancer. 2008;122:1253–1260
  21. Long KB, Hornick JL. Sox2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract. Hum Pathol. 2009;40:1768–1773
  22. Ponti D, Costa A, Zaffaroni N, et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res. 2005;65:5506–5511
  23. Avilion AA, Nicolis SK, Pevny LH, et al. Multipotent cell lineages in early mouse development depend on Sox2 function. Genes Dev. 2003;17:126–140
  24. Kopp JL, Ormsbee BD, Desler M, Rizzino A. Small increases in the level of Sox2 trigger the differentiation of Mouse embryonic stem cells. Stem Cell. 2008;26:903–911
  25. Chen Y, Shi L, Zhang L, et al. The molecular mechanism governing the oncogenic potential of Sox2 in breast cancer. J Biol Chem. 2008;283:17969–17978
  26. Peters WM. Nature of “basal” and “reserve” cells in oviductal and cervical epithelium in man. J Clin Pathol. 1986;39:306–312
  27. Smedts F, Ramaekers F, Troyanovsky S, et al. Basal-cell Keratins in cervical reserve cells and a comparison to their expression in cervical intraepithelial neoplasia. Am J Pathol. 1992;140:601–612
  28. Prasad NB, Biankin AV, Fukushima N, et al. Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of hedgehog signaling on pancreatic ductal epithelial cells. Cancer Res. 2005;65:1619–1626

☆ This research was supported by the National Natural Science Foundation of China (30571951/C1702; 30725043/C1702).

PII: S0046-8177(10)00113-9

doi: 10.1016/j.humpath.2009.11.021

Human Pathology
Volume 41, Issue 10 , Pages 1438-1447 , October 2010

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