Human Pathology
Volume 41, Issue 11 , Pages 1641-1645 , November 2010

Posttransplantation lymphoproliferative disease involving the pituitary gland

  • Zina Meriden, MD

      Affiliations

    • Department of Pathology, University of Virginia Health System, PO Box 800214, Charlottesville, VA 22908, USA
    • ,
  • Grant C. Bullock, MD, PhD

      Affiliations

    • Department of Pathology, University of Virginia Health System, PO Box 800214, Charlottesville, VA 22908, USA
    • ,
  • Adam Bagg, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    • ,
  • Hugo Bonatti, MD

      Affiliations

    • Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    • ,
  • John B. Cousar, MD

      Affiliations

    • Department of Pathology, University of Virginia Health System, PO Box 800214, Charlottesville, VA 22908, USA
    • ,
  • M. Beatriz Lopes, MD, PhD

      Affiliations

    • Department of Pathology, University of Virginia Health System, PO Box 800214, Charlottesville, VA 22908, USA
    • ,
  • Mark K. Robbins, MD

      Affiliations

    • Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    • ,
  • Helen P. Cathro, MBChB

      Affiliations

    • Department of Pathology, University of Virginia Health System, PO Box 800214, Charlottesville, VA 22908, USA
    • Corresponding Author InformationCorresponding author.

Received 27 October 2009 ,Revised 29 January 2010 ,Accepted 9 February 2010.

References 

  1. Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumours of haematopoietic and lymphoid tissue. Albany (NY): World Health Organization; 2008;
  2. Taylor AL, Marcus R, Bradley JA. Post-transplant lymphoproliferative disorders (PTLD) after solid organ transplantation. Crit Rev Oncol Hematol. 2005;56:155–167
  3. Bakker NA, van Imhoff GW, Verschuuren EA, et al. Presentation and early detection of post-transplant lymphoproliferative disorder after solid organ transplantation. Transpl Int. 2007;20:207–218
  4. Chadburn A, Cesarman E, Liu YF, et al. Molecular genetic analysis demonstrates that multiple posttransplantation lymphoproliferative disorders occurring in one anatomic site in a single patient represent distinct primary lymphoid neoplasms. Cancer. 1995;75:2747–2756
  5. Frankel AH, Thompson M, Vulliamy T, et al. A T cell clone in association with an Epstein-Barr virus–related B cell lymphoma. Transplantation. 1991;52:1108–1109
  6. Hollingsworth HC, Stetler-Stevenson M, Gagneten D, et al. Immunodeficiency-associated malignant lymphoma. Three cases showing genotypic evidence of both T- and B-cell lineages.. Am J Surg Pathol. 1994;18:1092–1101
  7. Morovic A, Jaffe ES, Raffeld M, et al. Metachronous EBV-associated B-cell and T-cell posttransplant lymphoproliferative disorders in a heart transplant recipient. Am J Surg Pathol. 2009;33:149–154
  8. Yin CC, Medeiros LJ, Abruzzo LV, et al. EBV-associated B- and T-cell posttransplant lymphoproliferative disorders following primary EBV infection in a kidney transplant recipient. Am J Clin Pathol. 2005;123:222–228
  9. Landman RE, Wardlaw SL, McConnell RJ, et al. Pituitary lymphoma presenting as fever of unknown origin. J Clin Endocrinol Metab. 2001;86:1470–1476
  10. Liu JK, Sayama C, Chin SS, et al. Extranodal NK/T-cell lymphoma presenting as a pituitary mass: case report and review of the literature. J Neurosurg. 2007;107:660–665
  11. Kaufmann TJ, Lopes MB, Laws ER, et al. Primary sellar lymphoma: radiologic and pathologic findings in two patients. AJNR Am J Neuroradiol. 2002;23:364–367
  12. Megan Ogilvie C, Payne S, Evanson J, et al. Lymphoma metastasizing to the pituitary: an unusual presentation of a treatable disease. Pituitary. 2005;8:139–146
  13. van Dongen JJM, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17:2257–2317
  14. Dotti G, Fiocchi R, Motta T, et al. Lymphomas occurring late after solid-organ transplantation: influence of treatment on the clinical outcome. Transplantation. 2002;74:1095–1102
  15. Paranjothi S, Yusen RD, Kraus MD, et al. Lymphoproliferative disease after lung transplantation: comparison of presentation and outcome of early and late cases. J Heart Lung Transplant. 2001;20:1054–1063

☆ Funding sources: Department of Pathology, University of Virginia Health System.

PII: S0046-8177(10)00135-8

doi: 10.1016/j.humpath.2010.02.015

Human Pathology
Volume 41, Issue 11 , Pages 1641-1645 , November 2010

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