Human Pathology
Volume 41, Issue 12 , Pages 1718-1725 , December 2010

Comprehensive keratin profiling reveals different histopathogenesis of keratocystic odontogenic tumor and orthokeratinized odontogenic cyst

  • Tadanobu Aragaki, DDS

      Affiliations

    • Section of Oral Pathology, Tokyo Medical and Dental University, Tokyo 113-0034, Japan
    • Section of Maxillofacial Surgery, Tokyo Medical and Dental University, Tokyo 113-0034, Japan
  • ,
  • Yasuyuki Michi, DDS, PhD

      Affiliations

    • Section of Maxillofacial Surgery, Tokyo Medical and Dental University, Tokyo 113-0034, Japan
  • ,
  • Ken-ichi Katsube, MD, PhD

      Affiliations

    • Section of Oral Pathology, Tokyo Medical and Dental University, Tokyo 113-0034, Japan
  • ,
  • Narikazu Uzawa, DDS, PhD

      Affiliations

    • Section of Maxillofacial Surgery, Tokyo Medical and Dental University, Tokyo 113-0034, Japan
  • ,
  • Norihiko Okada, DDS, PhD

      Affiliations

    • Section of Diagnostic Oral Pathology, Tokyo Medical and Dental University, Tokyo 113-0034, Japan
  • ,
  • Takumi Akashi, MD, PhD

      Affiliations

    • Department of Pathology, Tokyo Medical and Dental University, Tokyo 113-0034, Japan
  • ,
  • Teruo Amagasa, DDS, PhD

      Affiliations

    • Section of Maxillofacial Surgery, Tokyo Medical and Dental University, Tokyo 113-0034, Japan
  • ,
  • Akira Yamaguchi, DDS, PhD

      Affiliations

    • Section of Oral Pathology, Tokyo Medical and Dental University, Tokyo 113-0034, Japan
  • ,
  • Kei Sakamoto, DDS, PhD

      Affiliations

    • Section of Oral Pathology, Tokyo Medical and Dental University, Tokyo 113-0034, Japan
    • Corresponding Author InformationCorresponding author.

Received 25 February 2010 ,Revised 14 May 2010 ,Accepted 14 May 2010.

References 

  1. Gnepp DR. Diagnostic surgical pathology of the head and neck. 2nd ed.. Philadelpia, PA: Saunders; 2009;
  2. Gonzalez-Alva P, Tanaka A, Oku Y, et al. Keratocystic odontogenic tumor: a retrospective study of 183 cases. J Oral Sci. 2008;50:205–212
  3. Shear M. The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 2. Proliferation and genetic studies. Oral Oncol. 2002;38:323–331
  4. Kolar Z, Geierova M, Bouchal J, Pazdera J, Zboril V, Tvrdy P. Immunohistochemical analysis of the biological potential of odontogenic keratocysts. J Oral Pathol Med. 2006;35:75–80
  5. Madras J, Lapointe H. Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. J Can Dent Assoc. 2008;74:165-165h
  6. Ohki K, Kumamoto H, Ichinohasama R, Sato T, Takahashi N, Ooya K. PTC gene mutations and expression of SHH, PTC, SMO, and GLI-1 in odontogenic keratocysts. Int J Oral Maxillofac Surg. 2004;33:584–592
  7. Sun LS, Li XF, Li TJ. PTCH1 and SMO gene alterations in keratocystic odontogenic tumors. J Dent Res. 2008;87:575–579
  8. Zedan W, Robinson PA, Markham AF, High AS. Expression of the sonic hedgehog receptor “PATCHED” in basal cell carcinomas and odontogenic keratocysts. J Pathol. 2001;194:473–477
  9. In:  Barnes L,  Eveson JW,  Reichart P,  Sidransky D editor. Pathology and Genetics of Head and Neck Tumours. IARC WHO Classification of Tumours. No 9. Lyon France: IARC; 2005;
  10. Li TJ, Kitano M, Chen XM, et al. Orthokeratinized odontogenic cyst: a clinicopathological and immunocytochemical study of 15 cases. Histopathology. 1998;32:242–251
  11. Wright JM. The odontogenic keratocyst: orthokeratinized variant. Oral Surg Oral Med Oral Pathol. 1981;51:609–618
  12. Moll R, Divo M, Langbein L. The human keratins: biology and pathology. Histochem Cell Biol. 2008;129:705–733
  13. Shear M. The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 3. Immunocytochemistry of cytokeratin and other epithelial cell markers. Oral Oncol. 2002;38:407–415
  14. Stoll C, Stollenwerk C, Riediger D, Mittermayer C, Alfer J. Cytokeratin expression patterns for distinction of odontogenic keratocysts from dentigerous and radicular cysts. J Oral Pathol Med. 2005;34:558–564
  15. Vuhahula E, Nikai H, Ijuhin N, et al. Jaw cysts with orthokeratinization: analysis of 12 cases. J Oral Pathol Med. 1993;22:35–40
  16. Dos Santos JN, Oliveira GQ, Gurgel CA, et al. Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. J Mol Histol. 2009;
  17. Oriolo AS, Wald FA, Ramsauer VP, Salas PJ. Intermediate filaments: a role in epithelial polarity. Exp Cell Res. 2007;313:2255–2264
  18. McGowan K, Coulombe PA. The wound repair-associated keratins 6, 16, and 17. Insights into the role of intermediate filaments in specifying keratinocyte cytoarchitecture. Subcell Biochem. 1998;31:173–204
  19. Kim S, Wong P, Coulombe PA. A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature. 2006;441:362–365
  20. Yang SH, Andl T, Grachtchouk V, et al. Pathological responses to oncogenic hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet. 2008;40:1130–1135
  21. Grachtchouk M, Mo R, Yu S, et al. Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet. 2000;24:216–217
  22. Bianchi N, Depianto D, McGowan K, Gu C, Coulombe PA. Exploiting the keratin 17 gene promoter to visualize live cells in epithelial appendages of mice. Mol Cell Biol. 2005;25:7249–7259
  23. Grachtchouk M, Liu J, Wang A, et al. Odontogenic keratocysts arise from quiescent epithelial rests and are associated with deregulated hedgehog signaling in mice and humans. Am J Pathol. 2006;169:806–814
  24. Regl G, Kasper M, Schnidar H, et al. Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Cancer Res. 2004;64:7724–7731

 This work was supported by a grant-in-aid from the Japanese Ministry of Education, Culture, Sports, Science, and Technology (Kakenhi 21592320), Tokyo, Japan.

PII: S0046-8177(10)00185-1

doi: 10.1016/j.humpath.2010.05.007

Human Pathology
Volume 41, Issue 12 , Pages 1718-1725 , December 2010