Multiple chromosomal monosomies are characteristic of giant cell ependymoma

Dahlback, Hanne-Sofie S.; Brandal, Petter; Krossnes, Bård K.; Fric, Radek; Meling, Torstein R.; Meza-Zepeda, Leonardo A.; Danielsen, Håvard E.; Heim, Sverre

doi:10.1016/j.humpath.2011.02.012

« Previous Next »Human Pathology
Volume 42, Issue 12 , Pages 2042-2046, December 2011

Multiple chromosomal monosomies are characteristic of giant cell ependymoma

Hanne-Sofie S. Dahlback, MD
- Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway
- Centre for Cancer Biomedicine, University of Oslo, 0310 Oslo, Norway
- Institute for Clinical Medicine, Medical Faculty, University of Oslo, 0316 Oslo, Norway
- Corresponding author. Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway.
Petter Brandal, MD, PhD
- Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway
- Centre for Cancer Biomedicine, University of Oslo, 0310 Oslo, Norway
- Department of Oncology, Division of Cancer and Surgery, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, 0316 Oslo, Norway
Bård K. Krossnes, MD
- Department of Pathology, Rikshospitalet, Oslo University Hospital, 0372 Oslo, Norway
Radek Fric, MD
- Department of Neurosurgery, Rikshospitalet, Oslo University Hospital, 0372 Oslo, Norway
Torstein R. Meling, MD, PhD
- Department of Neurosurgery, Rikshospitalet, Oslo University Hospital, 0372 Oslo, Norway
Leonardo A. Meza-Zepeda, PhD
- Department of Tumor Biology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway
- Norwegian Microarray Consortium, Department of Molecular Biosciences, University of Oslo, 0310 Oslo, Norway
Håvard E. Danielsen, PhD
- Centre for Cancer Biomedicine, University of Oslo, 0310 Oslo, Norway
- Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway
- Department of Informatics, University of Oslo, 0316 Oslo, Norway
Sverre Heim, MD, PhD
- Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway
- Centre for Cancer Biomedicine, University of Oslo, 0310 Oslo, Norway
- Institute for Clinical Medicine, Medical Faculty, University of Oslo, 0316 Oslo, Norway

Received 15 December 2010; received in revised form 3 February 2011; accepted 18 February 2011. published online 20 June 2011.

Summary

Giant cell ependymoma, a rare ependymoma subtype, was recently recognized as a separate diagnostic entity with variations both in malignant potential and course of disease. We analyzed the first supratentorial giant cell ependymoma using G-band karyotyping, DNA ploidy analysis, and array comparative genomic hybridization. The tumor was hypodiploid, and the karyotype showed multiple monosomies. This novel cytogenetic pattern seems specific for giant cell ependymoma as the only previous cytogenetic analysis of a giant cell ependymoma found similar monosomies. We were also able to analyze cytogenetically the subsequent recurrent tumor, phenotypically an anaplastic ependymoma, allowing a first insight into the genetic events involved in disease progression.

Keywords: Giant cell ependymoma, Anaplastic ependymoma, Karyotyping, Aneuploidy, DNA ploidy analysis, Array comparative genomic hybridization