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Article Title |
Author(s) |
Type (Status) |
Available Online |
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A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst)
DOI: 10.1016/j.humpath.2011.10.003
Abstract: Aneurysmal bone cyst is a rapidly growing and locally aggressive lesion that commonly affects children and young adults. Initially regarded as a reactive process, primary aneurysmal bone cys...
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Zenggang Pan,
Warren G. Sanger,
Julia A. Bridge,
William J. Hunter,
Gene P. Siegal,
Shi Wei
et al.
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Short communication
(In Press Corrected Proof)
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27 January 2012 |
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An immunohistochemical comparison of cytokeratin 7, cytokeratin 15, cytokeratin 19, CAM 5.2, carcinoembryonic antigen, and nestin in differentiating porocarcinoma from squamous cell carcinoma
DOI: 10.1016/j.humpath.2011.10.005
Summary: The distinction of porocarcinoma from squamous cell carcinoma is clinically relevant but can often be a diagnostic dilemma. Current markers reported to be helpful in diagnosing porocarcinoma ...
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Meera Mahalingam,
Joanna E. Richards,
M. Angelica Selim,
Alona Muzikansky,
Mai P. Hoang
et al.
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Full-length article
(In Press Corrected Proof)
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27 January 2012 |
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Ectopic hepatic tissue presenting as right atrial mass
DOI: 10.1016/j.humpath.2011.10.004
Summary: A 52-year-old woman had a well-circumscribed, mobile mass (1.8 × 1.7 cm) in the right atrium detected by echocardiography and confirmed by magnetic resonance imaging. Subsequent histologic ev...
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Lauren Xu,
Jean Jeudy,
Allen P. Burke
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Short communication
(In Press Corrected Proof)
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25 January 2012 |
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Importance of muscle light microscopic mitochondrial subsarcolemmal aggregates in the diagnosis of respiratory chain deficiency
DOI: 10.1016/j.humpath.2011.09.016
Summary: The purpose of this study was to evaluate relationships between subsarcolemmal mitochondrial aggregates and electron transport chain deficiencies in skeletal muscle with the objective of esta...
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Lili Miles,
Michael V. Miles,
Paul S. Horn,
Ton J. DeGrauw,
Brenda L. Wong,
Kevin E. Bove
et al.
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Full-length article
(In Press Corrected Proof)
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25 January 2012 |
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Erratum to “Counting myenteric ganglion cells in histologic sections: an empirical approach” [Hum Pathol 2010;41:1097-1108]
DOI: 10.1016/j.humpath.2012.01.001
In the abovementioned article, the authors have noted that the citation information for reference 39 is incorrect. The correct reference should be: Koletzko S, Jesch I, Faus-Kessler T, et al. Rectal b...
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Maya Swaminathan,
Raj P. Kapur
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Erratum
(In Press Corrected Proof)
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16 January 2012 |
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The diagnostic utility of the GNAS mutation in patients with fibrous dysplasia: meta-analysis of 168 sporadic cases
DOI: 10.1016/j.humpath.2011.09.012
Summary: GNAS mutations have been implicated in the development of fibrous dysplasia and multiple endocrinopathies of the Albright-McCune syndrome. To investigate the diagnostic utility of GNAS mutati...
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Seung Eun Lee,
Enu Hee Lee,
Heejung Park,
Ji-Youn Sung,
Hyoun Wook Lee,
So Young Kang,
Sungwook Seo,
Byung Heon Kim,
Hyojin Lee,
An Na Seo,
Geunghwan Ahn,
Yoon-La Choi
et al.
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma
DOI: 10.1016/j.humpath.2011.10.010
Summary: Lysine-specific demethylase 1 (GeneID 23028), a flavin-dependent monoamine oxidoreductase and a histone demethylase, serves as an epigenetic coregulator of transcription. Lysine-specific deme...
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Idriss M. Bennani-Baiti,
Isidro Machado,
Antonio Llombart-Bosch,
Heinrich Kovar
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Oral extragonadal yolk sac tumor in a patient with Aicardi syndrome: putative origin and differential diagnosis
DOI: 10.1016/j.humpath.2011.09.015
Summary: We report, for the first time, a primary oral presentation of a germ cell yolk sac tumor in a 4-year-old girl with Aicardi syndrome. The diagnosis, differential diagnosis, and histogenesis ar...
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Rhonda Burch-Smith,
Nelson G. Ordonez,
Lawrence E. Ginsberg,
Joann L. Ater,
Adel K. El Naggar
et al.
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Short communication
(In Press Corrected Proof)
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06 January 2012 |
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Silencing of homeobox B9 is associated with down-regulation of CD56 and extrathyroidal extension of tumor in papillary thyroid carcinoma
DOI: 10.1016/j.humpath.2011.09.008
Summary: Papillary thyroid carcinoma is the most common type of thyroid malignancy, and CD56, a neural cell adhesion molecule, is typically down-regulated in almost all cases of papillary thyroid carc...
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Jang-Hee Kim,
Young Hwa Kim,
Jae Ho Han,
Kyi Beom Lee,
Seung Soo Sheen,
Jandee Lee,
Euy-Young Soh,
Tae Jun Park
et al.
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Full-length article
(In Press Corrected Proof)
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06 January 2012 |
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Significance of E-cadherin, β-catenin, and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma
DOI: 10.1016/j.humpath.2011.08.025
Summary: Although early-stage cervical cancer can be treated by surgery, distant metastases can be life threatening. It has been a challenge to identify reliable biomarkers as indicators of metastasis...
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Yong Cheng,
Ying Zhou,
Wenjing Jiang,
Xia Yang,
Jing Zhu,
Dingqing Feng,
Ying Wei,
Min Li,
Fengqiu Yao,
Weiping Hu,
Weihua Xiao,
Bin Ling
et al.
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Full-length article
(In Press Corrected Proof)
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05 January 2012 |
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Mantle cell lymphoma as a component of composite lymphoma: clinicopathologic parameters and biologic implications
DOI: 10.1016/j.humpath.2011.08.024
Summary: Composite lymphoma is a rare circumstance in which 2 or more distinct types of lymphoma occur in a single anatomical location. Although composite lymphoma has been increasingly identified wit...
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Thomas G. Papathomas,
Ioannis Venizelos,
Cherie H. Dunphy,
Jonathan W. Said,
Michael L. Wang,
Elias Campo,
Steven H. Swerdlow,
John C. Chan,
Carlos E. Bueso-Ramos,
Dennis D. Weisenburger,
L. Jeffrey Medeiros,
Ken H. Young
et al.
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Short communication
(In Press Corrected Proof)
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05 January 2012 |
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Foamy gland adenocarcinoma of the prostate: incidence, Gleason grade, and early clinical outcome
DOI: 10.1016/j.humpath.2011.09.009
Summary: Foamy gland carcinoma is a variant of prostatic acinar adenocarcinoma characterized by abundant foamy cytoplasm and often pyknotic nuclei. Limited data exist regarding outcome and the clinico...
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Jena Hudson,
Dengfeng Cao,
Robin Vollmer,
Adam S. Kibel,
Shaun Grewal,
Peter A. Humphrey
et al.
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Full-length article
(In Press Corrected Proof)
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05 January 2012 |
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Loss of heterozygosity of the PTCH gene in ameloblastoma
DOI: 10.1016/j.humpath.2011.08.026
Summary: Ameloblastoma is a locally aggressive benign neoplasm derived from odontogenic epithelium, with high recurrence rates. Alterations in the Sonic Hedgehog signaling pathway, including PTCH gene...
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Lucyana Conceição Farias,
Carolina Cavalieri Gomes,
João Artur Ricieri Brito,
Clarice Ferreira Galvão,
Marina Gonçalves Diniz,
Wagner Henriques de Castro,
Vanessa de Fátima Bernardes,
Luiz Armando De Marco,
Ricardo Santiago Gomez
et al.
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Full-length article
(In Press Corrected Proof)
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05 January 2012 |
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Factors associated with residual disease after initial breast-conserving surgery for ductal carcinoma in situ
DOI: 10.1016/j.humpath.2011.09.010
Summary: Breast-conserving surgery with radiation therapy has become a standard treatment option in women with localized ductal carcinoma in situ. Re-excision is common in breast-conserving surgery, p...
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Shi Wei,
Christopher P. Kragel,
Kui Zhang,
Omar Hameed
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Full-length article
(In Press Corrected Proof)
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05 January 2012 |
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Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases
DOI: 10.1016/j.humpath.2011.08.023
Summary: Ganglioglioma and dysembryoplastic neuroepithelial tumor are both low-grade glioneuronal neoplasms that most commonly occur in association with chronic epilepsy. Rare cases of tumors with com...
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Richard A. Prayson,
Karl M. Napekoski
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Full-length article
(In Press Corrected Proof)
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05 January 2012 |
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HMGA gene rearrangement is a recurrent somatic alteration in polypoid endometriosis
DOI: 10.1016/j.humpath.2011.09.013
Summary: The pathogenesis of endometriosis is unclear, and several genetic, endocrine, immune, and environmental agents have been evaluated with no putative causative factors identified. Here, we show...
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Fabiola Medeiros,
Xiaoke Wang,
Ana Rose C. Araujo,
Michele R. Erickson-Johnson,
Joema F. Lima,
Alexandra Meuter,
Boris Winterhoff,
Andre M. Oliveira
et al.
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Full-length article
(In Press Corrected Proof)
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05 January 2012 |
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Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement
DOI: 10.1016/j.humpath.2011.09.014
Summary: Pancreatic neuroendocrine tumors with prominent stromal fibrosis are often clinically, radiographically, and grossly indistinguishable from ductal adenocarcinoma. We recently described a smal...
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Chad M. McCall,
Chanjuan Shi,
Alison P. Klein,
Björn Konukiewitz,
Barish H. Edil,
Trevor A. Ellison,
Christopher L. Wolfgang,
Richard D. Schulick,
Günter Klöppel,
Ralph H. Hruban
et al.
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Full-length article
(In Press Corrected Proof)
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05 January 2012 |
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Human epithelial growth factor receptor 2 (HER2) status in primary and metastatic esophagogastric junction adenocarcinomas
DOI: 10.1016/j.humpath.2011.09.004
Summary: Differences in human epithelial growth factor receptor 2 dysregulation in primary solid tumors and metastases may (at least partially) explain human epithelial growth factor receptor 2–target...
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Matteo Fassan,
Kathrin Ludwig,
Marco Pizzi,
Carlo Castoro,
Vincenza Guzzardo,
Mariangela Balistreri,
Giovanni Zaninotto,
Alberto Ruol,
Luciano Giacomelli,
Ermanno Ancona,
Massimo Rugge
et al.
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Full-length article
(In Press Corrected Proof)
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04 January 2012 |
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On being a pathologist: a brief chronicle of an academic surgical pathologist
DOI: 10.1016/j.humpath.2011.09.007
I was born in a small rural town of approximately 400 people named La Concordia (The Concord) in Chiapas, a southeastern state of Mexico. My father jokingly used to tell me that a better name for the ...
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Jorge Albores-Saavedra
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Short communication
(In Press Corrected Proof)
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03 January 2012 |
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PIK3CA mutations in endometrial carcinomas in Chinese women: phosphatidylinositol 3′-kinase pathway alterations might be associated with favorable prognosis
DOI: 10.1016/j.humpath.2011.08.021
Summary: The aim of this study was to determine the clinicopathological impact of PIK3CA mutations and phosphatidylinositol 3′-kinase pathway alterations in endometrial cancers in Chinese women. The P...
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Ying Dong,
Xi Yang,
Oscar Wong,
Xiaoming Zhang,
Ying Liang,
Ying Zhang,
Wei Wong,
Lin Nong,
Qinping Liao,
Ting Li
et al.
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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Thyroid paraganglioma. Report of 3 cases and description of an immunohistochemical profile useful in the differential diagnosis with medullary thyroid carcinoma, based on complementary DNA array results
DOI: 10.1016/j.humpath.2011.08.022
Summary: Thyroid paraganglioma is a rare disorder that sometimes poses problems in differential diagnosis with medullary thyroid carcinoma. So far, differential diagnosis is solved with the help of so...
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Esmeralda Castelblanco,
Pilar Gallel,
Susana Ros,
Sonia Gatius,
Joan Valls,
Aguirre A. De-Cubas,
Agnieszka Maliszewska,
M. Teresa Yebra-Pimentel,
Javier Menarguez,
Carlos Gamallo,
Giuseppe Opocher,
Mercedes Robledo,
Xavier Matias-Guiu
et al.
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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“Intrafollicular neoplasia” of nodular lymphocyte predominant Hodgkin lymphoma: Description of a hypothetic early step of the disease
DOI: 10.1016/j.humpath.2011.09.002
Summary: The 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues has addressed the problem of intrafollicular neoplasia/“in situ” lesion for follicular lymphoma. The concept of i...
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Antonino Carbone,
Annunziata Gloghini
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Short communication
(In Press Corrected Proof)
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03 January 2012 |
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Loss of nuclear expression of Krüppel-like factor 4 is associated with poor prognosis in patients with oral cancer
DOI: 10.1016/j.humpath.2011.09.003
Summary: Krüppel-like factor 4 is not only involved in cell proliferation but also affects cell differentiation and extracellular matrix production via positive and negative regulation of the expressi...
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Chih-Jung Chen,
Li-Sung Hsu,
Shu-Hui Lin,
Mu-Kuan Chen,
Hsin-Kai Wang,
Jeng-Dong Hsu,
Huei Lee,
Kun-Tu Yeh
et al.
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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Immunohistochemical expression profile of β-catenin, E-cadherin, P-cadherin, laminin-5γ2 chain, and SMAD4 in colorectal serrated adenocarcinoma
DOI: 10.1016/j.humpath.2011.08.020
Summary: The immunohistochemical expression of cell adhesion molecules in colorectal serrated adenocarcinoma is still unknown. The immunostaining patterns of β-catenin, E-cadherin, P-cadherin, laminin...
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José García-Solano,
Pablo Conesa-Zamora,
Javier Trujillo-Santos,
Daniel Torres-Moreno,
Markus J. Mäkinen,
Miguel Pérez-Guillermo
et al.
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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Assessment of the prognostic significance of endoglin (CD105) in clear cell renal cell carcinoma using automated image analysis
DOI: 10.1016/j.humpath.2011.08.012
Summary: The behavior of clear cell renal cell carcinoma can be difficult to predict. Angiogenesis has proven to be a useful prognostic indicator in different malignancies. Endoglin (CD105) is a new m...
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William Dubinski,
Manal Gabril,
Vladimir V. Iakovlev,
Andreas Scorilas,
Youssef M. Youssef,
Hala Faragalla,
Kalman Kovacs,
Fabio Rotondo,
Shereen Metias,
Androu Arsanious,
Anna Plotkin,
Andrew H.F. Girgis,
Catherine J. Streutker,
George M. Yousef
et al.
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Full-length article
(In Press Corrected Proof)
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28 December 2011 |
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Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non–small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression
DOI: 10.1016/j.humpath.2011.08.017
Summary: Expression of astrocyte-elevated gene-1, a novel oncoprotein, is elevated in multiple cancers and plays a vital role in tumor cell growth, invasion, angiogenesis, and progression to metastasi...
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Shijun Sun,
Zunfu Ke,
Fen Wang,
Shuhua Li,
Wenfang Chen,
Anjia Han,
Zuo Wang,
Huijuan Shi,
Lian-tang Wang,
Xiaodong Chen
et al.
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Full-length article
(In Press Corrected Proof)
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28 December 2011 |
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The Wnt/β-catenin pathway drives increased cyclin D1 levels in lymph node metastasis in papillary thyroid cancer
DOI: 10.1016/j.humpath.2011.08.013
Summary: We examined the expression of cyclin D1 in conjunction with β-catenin and the phosphorylated inactive form of glycogen synthase kinase 3β (GSK-3β) in benign, nonneoplastic thyroid tissue as w...
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Jingdong Zhang,
Anthony J.M. Gill,
Joseph D. Issacs,
Bryn Atmore,
Amber Johns,
Leigh W. Delbridge,
Raymond Lai,
Todd P.W. McMullen
et al.
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Full-length article
(In Press Corrected Proof)
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28 December 2011 |
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Utilization of fluorescence in situ hybridization with cytokeratin discriminators in TOP2A assessment of chemotherapy-treated patients with breast cancer
DOI: 10.1016/j.humpath.2011.08.018
Summary: Tumor biomarkers increasingly provide information for predicting outcomes with chemotherapeutic regimens (personalized medicine). Topo2A is a DNA helicase targeted by anthracyclines, cytotoxi...
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William E. Pierceall,
Kam M. Sprott,
Tuomas Heikkinen,
Paivi Heikkila,
Lakshmi Alaparthi,
Kristiina Aittomaki,
Mohammed Al-Adhami,
Vivian Villegas-Bergazzi,
Jane L. Meyer,
Jeffery L. Kutok,
Jirina Bartkova,
Jiri Bartek,
Heli Nevanlinna,
David T. Weaver,
Carl Blomqvist
et al.
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Full-length article
(In Press Corrected Proof)
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28 December 2011 |
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Extracutaneous Merkel cell carcinomas harbor polyomavirus DNA
DOI: 10.1016/j.humpath.2011.08.014
Summary: Merkel cell carcinoma is a neuroendocrine tumor, with characteristic morphological and immunohistochemical features. Originally reported as primary carcinoma of skin, it has been described in...
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Dario de Biase,
Moira Ragazzi,
Sofia Asioli,
Vincenzo Eusebi
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Full-length article
(In Press Corrected Proof)
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28 December 2011 |
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Morphology and prognostic value of tumor budding in rectal cancer after neoadjuvant radiotherapy
DOI: 10.1016/j.humpath.2011.07.026
Summary: Tumor budding is an acknowledged prognostic marker in colorectal cancer. This study was conducted to investigate the morphology and prognostic significance of budding in rectal cancer after n...
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Changzheng Du,
Weicheng Xue,
Jiyou Li,
Yong Cai,
Jin Gu
et al.
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Full-length article
(In Press Corrected Proof)
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28 December 2011 |
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High density of tryptase-positive mast cells in patients with renal cell carcinoma on hemodialysis: correlation with expression of stem cell factor and protease activated receptor-2
DOI: 10.1016/j.humpath.2011.07.019
Summary: Patients on hemodialysis are at higher risk of renal cell carcinoma probably because of inflammatory and immune system disorders. The aim of this study was to clarify the pathologic roles of ...
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Shin-ichi Watanabe,
Yasuyoshi Miyata,
Tomohiro Matsuo,
Yasushi Mochizuki,
Masaharu Nishikido,
Tomayoshi Hayashi,
Hideki Sakai
et al.
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Full-length article
(In Press Corrected Proof)
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28 December 2011 |
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Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase–like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma
DOI: 10.1016/j.humpath.2011.07.027
Summary: Lysyl oxidase family members have various roles in cancer progression. The aim of this study was to investigate their expression and clinical significance in esophageal squamous cell carcinom...
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Tian-Yu Li,
Li-Yan Xu,
Zhi-Yong Wu,
Lian-Di Liao,
Jin-Hui Shen,
Xiu-E Xu,
Ze-Peng Du,
Qing Zhao,
En-Min Li
et al.
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Full-length article
(In Press Corrected Proof)
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28 December 2011 |
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Clinicopathologic significance and function of S-phase kinase-associated protein 2 overexpression in hepatocellular carcinoma
DOI: 10.1016/j.humpath.2011.08.019
Summary: The F-box protein S-phase kinase-associated protein 2 is frequently overexpressed in human cancers. Herein, we aimed to investigate the expression pattern, clinical significance, and biologic...
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Shu-Hui Zhang,
Yi-Ming Qian,
An-Wen Liu,
Jing Cai,
Xiang-Li Zhao,
Jing-Jing Wei,
Ming-Hua Zhu
et al.
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Full-length article
(In Press Corrected Proof)
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28 December 2011 |
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Cytogenetic and molecular genetic study on glioblastoma arising in granular cell astrocytoma: a case report
DOI: 10.1016/j.humpath.2011.08.015
Summary: Granular cell astrocytoma is a rare infiltrative malignant glioma with prominent granular cell change. Granular cell astrocytomas are biologically aggressive compared with conventional infilt...
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Mee Joo,
Sung-Hye Park,
Sun Hee Chang,
Hanseong Kim,
Chan-Young Choi,
Chae-Heuck Lee,
Byung Hoon Lee,
Yoon Joon Hwang
et al.
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Short communication
(In Press Corrected Proof)
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28 December 2011 |
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Expression of therapeutic targets in Ewing sarcoma family tumors
DOI: 10.1016/j.humpath.2011.09.001
Summary: Ewing sarcoma family tumor is an aggressive malignant tumor of bone and soft tissue in children and adolescents. Despite advances in modern therapy, metastasis occurs in 20% to 25% of cases a...
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Atif A. Ahmed,
Ashley K. Sherman,
Bruce R. Pawel
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Full-length article
(In Press Corrected Proof)
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23 December 2011 |
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Unusual thyroid carcinoma with excessive extracellular hyaline globules: a case of “hyalinizing papillary carcinoma”
DOI: 10.1016/j.humpath.2011.08.010
Summary: We present an unusual case of papillary thyroid carcinoma in a 47-year-old Japanese woman. The tumor, 0.8 cm in diameter, was located in the upper left lobe of the thyroid. Histologically, we...
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Tetsuo Kondo,
Tadao Nakazawa,
Nobuo Terada,
Kumiko Nakazawa,
Tomonori Kawasaki,
Kunio Mochizuki,
Tetsu Yamane,
Shinichi Ohno,
Ryohei Katoh
et al.
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Short communication
(In Press Corrected Proof)
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16 December 2011 |
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NEMO expression in human hepatocellular carcinoma and its association with clinical outcome
DOI: 10.1016/j.humpath.2011.08.009
Summary: The nuclear factor κ-light-chain enhancer of activated B-cells (NF-κB) signaling pathway is regarded as an important factor in inflammation and carcinogenesis. Recently, a role in hepatocarci...
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Ariane Aigelsreiter,
Johannes Haybaeck,
Silvia Schauer,
Tobias Kiesslich,
Kira Bettermann,
Antonia Griessbacher,
Tatjana Stojakovic,
Thomas Bauernhofer,
Hellmut Samonigg,
Peter Kornprat,
Carolin Lackner,
Martin Pichler
et al.
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Full-length article
(In Press Corrected Proof)
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16 December 2011 |
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Expression of CXCR4 indicates poor prognosis in patients with clear cell carcinoma of the ovary
DOI: 10.1016/j.humpath.2011.08.002
Summary: Recent reports have shown that CXCR4 is expressed in various solid tumors and is involved in tumor development and metastasis. We examined the distribution and expression of this molecule in ...
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Ryuichiro Sekiya,
Hiroaki Kajiyama,
Kotaro Sakai,
Tomokazu Umezu,
Mika Mizuno,
Kiyosumi Shibata,
Eiko Yamamoto,
Sawako Fujiwara,
Tetsuro Nagasaka,
Fumitaka Kikkawa
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: a pathological study of 139 lesions in 121 patients
DOI: 10.1016/j.humpath.2011.07.025
Summary: We are presenting the morphological features of 121 cases of atypical penile intraepithelial lesions. The term penile intraepithelial neoplasia (PeIN) was used to encompass all of them, and l...
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Alcides Chaux,
Elsa F. Velazquez,
Ali Amin,
Ana Soskin,
Rolf Pfannl,
Ingrid M. Rodríguez,
José E. Barreto,
Cecilia Lezcano,
Gustavo Ayala,
George J. Netto,
Antonio L. Cubilla
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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Progression of morphological changes after transplantation of a liver with heterozygous α-1 antitrypsin deficiency
DOI: 10.1016/j.humpath.2011.08.001
Summary: Inadvertent transplantation of an α-1 antitrypsin–deficient liver into an adult man provided a unique opportunity to follow the natural history of morphological changes in serial liver biopsi...
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Sun-Mi Lee,
K. Vincent Speeg,
Marilyn S. Pollack,
Francis E. Sharkey
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Full-length article
(In Press Corrected Proof)
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12 December 2011 |
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Evaluation of the detection of melanin by the Fontana-Masson silver stain in tissue with a wide range of organisms including Cryptococcus
DOI: 10.1016/j.humpath.2011.07.021
Summary: It is not uncommon for surgical pathologists to encounter yeast and yeast-like organisms in tissue sections, and correct identification is imperative for guiding therapy. The Fontana-Masson s...
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Justin A. Bishop,
Ann Marie Nelson,
William G. Merz,
Frederic B. Askin,
Stefan Riedel
et al.
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Full-length article
(In Press Corrected Proof)
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12 December 2011 |
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EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis
DOI: 10.1016/j.humpath.2011.08.006
Summary: Increased gene copy number (high polysomy or amplification) of EGFR and HER2 has evolved as a predictor for response to targeted therapy. STAT3 and the apoptosis inhibitor survivin represent ...
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Tobias Ettl,
Clemens Stiegler,
Katharina Zeitler,
Abbas Agaimy,
Johannes Zenk,
Torsten E. Reichert,
Martin Gosau,
Thomas Kühnel,
Gero Brockhoff,
Stephan Schwarz
et al.
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Full-length article
(In Press Corrected Proof)
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12 December 2011 |
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Androgen receptor expression is usually maintained in initial surgically resected breast cancer metastases but is often lost in end-stage metastases found at autopsy
DOI: 10.1016/j.humpath.2011.08.007
Summary: Androgen receptor (AR) is expressed in approximately 70% of primary breast carcinomas (PBCs) and is a promising therapeutic target for metastatic breast carcinoma (MBC). Here, we examine AR e...
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Ashley Cimino-Mathews,
Jessica L. Hicks,
Peter B. Illei,
Marc K. Halushka,
John H. Fetting,
Angelo M. De Marzo,
Ben Ho Park,
Pedram Argani
et al.
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Full-length article
(In Press Corrected Proof)
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12 December 2011 |
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MAPK7 and MAP2K4 as prognostic markers in osteosarcoma
DOI: 10.1016/j.humpath.2011.08.003
Summary: Osteosarcoma is a class of cancer originating from the bone, affecting mainly children and young adults. Cytogenetic studies showed the presence of rearrangements and recurrent gains in speci...
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Francine Tesser-Gamba,
Antonio Sergio Petrilli,
Maria Teresa de Seixas Alves,
Reynaldo Jesus Garcia Filho,
Yara Juliano,
Sílvia Regina Caminada Toledo
et al.
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Full-length article
(In Press Corrected Proof)
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12 December 2011 |
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c-kit gene mutation and CD117 expression in human anorectal melanomas
DOI: 10.1016/j.humpath.2011.08.005
Summary: c-kit and BRAF mutations play an important role during the pathogenesis of melanoma. The subtypes of melanomas arising from different parts of the body have variable c-kit or BRAF mutation fr...
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Shujuan Ni,
Dan Huang,
Xiaochen Chen,
Jiaying Huang,
Yunyi Kong,
Ye Xu,
Xiang Du,
Weiqi Sheng
et al.
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Full-length article
(In Press Corrected Proof)
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12 December 2011 |
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EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report
DOI: 10.1016/j.humpath.2011.08.004
Summary: Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangeme...
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Uta Flucke,
Thomas Mentzel,
Marian A. Verdijk,
Pieter J. Slootweg,
David H. Creytens,
Albert J.H. Suurmeijer,
Bastiaan B.J. Tops
et al.
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Short communication
(In Press Corrected Proof)
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09 December 2011 |
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Gastric schwannoma: a clinicopathologic study of 51 cases and critical review of the literature
DOI: 10.1016/j.humpath.2011.07.006
Summary: Schwannoma is a rare gastrointestinal mesenchymal tumor, as the vast majority of gastric mesenchymal tumors are gastrointestinal stromal tumors. In this study, we analyzed clinicopathological...
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Lysandra Voltaggio,
Rebecca Murray,
Jerzy Lasota,
Markku Miettinen
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Full-length article
(In Press Corrected Proof)
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02 December 2011 |
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Large cell neuroendocrine carcinoma arising in a sessile serrated adenoma: a novel observation
DOI: 10.1016/j.humpath.2011.07.022
Summary: A 68-year-old woman underwent polypectomy of 2 right-sided colonic polyps identified by screening colonoscopy. Histologic examination of both polyps showed features of sessile serrated adenom...
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Karen Naert,
Marc P. Dupre
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Short communication
(In Press Corrected Proof)
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14 November 2011 |
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Nosology: infarction hematoma, a placental infarction encasing a hematoma
DOI: 10.1016/j.humpath.2011.07.023
Summary: Six cases of mothers whose placentas demonstrate multiple infarctions with a central intraparenchymal hematoma are presented. The histology is distinct from intervillous thrombus and Kline he...
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Robert W. Bendon
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Short communication
(In Press Corrected Proof)
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14 November 2011 |
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Histologic abnormalities of placental tissues in Fabry disease: a case report and review of the literature
DOI: 10.1016/j.humpath.2011.07.020
Summary: Fabry disease is an X-linked lysosomal storage disease caused by deficiency of α-galactosidase A, resulting in the accumulation of globotriaosylceramide. Many women experience symptoms, but t...
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Beth L. Thurberg,
Juan M. Politei
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Short communication
(In Press Corrected Proof)
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14 November 2011 |
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E-cadherin nuclear staining is useful for the diagnosis of ovarian adult granulosa cell tumor
DOI: 10.1016/j.humpath.2011.07.018
Summary: We recently have demonstrated nuclear localization of E-cadherin in ovarian adult granulosa cell tumors (Histopathology 2011;58:423). The purpose of the present study is to investigate the di...
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Yoshihiro Ohishi,
Shuichi Kurihara,
Tadahisa Takeuchi,
Murasaki Aman,
Tsunehisa Kaku,
Hiroaki Kobayashi,
Norio Wake,
Yoshinao Oda
et al.
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Full-length article
(In Press Corrected Proof)
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14 November 2011 |
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Composition and significance of splenic Gamna-Gandy bodies in sickle cell anemia
DOI: 10.1016/j.humpath.2011.08.011
Summary: Children with sickle cell anemia may undergo acute splenic sequestration. Splenectomy is performed in an attempt to reduce further events. Histologic studies of spleens have revealed the pres...
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Andrea Piccin,
Hala Rizkalla,
Owen Smith,
Corrina McMahon,
Claudio Furlan,
Ciaran Murphy,
Giovanni Negri,
Michael Mc Dermott
et al.
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Full-length article
(In Press Corrected Proof)
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14 November 2011 |
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Relationship between alpha-methylacyl–coenzyme A racemase expression and mucin phenotype in gastric cancer
DOI: 10.1016/j.humpath.2011.07.017
Summary: Alpha-methylacyl–coenzyme A racemase controls β-oxidation of branched-chain fatty acid and their derivatives. Many investigators have described alpha-methylacyl–coenzyme A racemase expression...
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Yujiro Nozawa,
Ken Nishikura,
Yoichi Ajioka,
Yutaka Aoyagi
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Full-length article
(In Press Corrected Proof)
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14 November 2011 |
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Total parenteral nutrition therapy and liver injury: a histopathologic study with clinical correlation
DOI: 10.1016/j.humpath.2011.07.008
Summary: Total parenteral nutrition (TPN) therapy is a well-recognized cause of liver injury. The histologic changes attributed to TPN in the literature vary widely. In this study, we describe the his...
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Bita V. Naini,
Charles R. Lassman
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Full-length article
(In Press Corrected Proof)
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11 November 2011 |
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Anaplastic thymic carcinoma: a clinicopathologic and immunohistochemical study of 6 cases
DOI: 10.1016/j.humpath.2011.07.015
Summary: Primary thymic anaplastic (“undifferentiated”) carcinoma is an unusual thymic neoplasm that, to date, has not been properly characterized. We present 6 such cases in an attempt to better defi...
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Annikka Weissferdt,
Cesar A. Moran
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Full-length article
(In Press Corrected Proof)
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07 November 2011 |
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Pancreatic acinar-like adenocarcinoma of the proximal stomach invading the esophagus
DOI: 10.1016/j.humpath.2011.07.024
Summary: The aim of this study was to systematically investigate clinicopathologic features of the recently described pancreatic acinar-like adenocarcinoma of the proximal stomach invading the esophag...
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Qin Huang,
Jason S. Gold,
Jiong Shi,
Xiangshan Fan,
Hongyan Wu,
Anning Feng,
Qiang Zhou
et al.
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Full-length article
(In Press Corrected Proof)
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07 November 2011 |
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Total Survivin and acetylated Survivin correlate with distinct molecular subtypes of breast cancer
DOI: 10.1016/j.humpath.2011.07.014
Summary: Global gene expression profiling studies led to the recent classification of breast cancer into 4 distinct molecular subtypes including luminal, human epidermal growth factor receptor 2 enric...
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Evgeny Yakirevich,
Ayman Samkari,
Michael P. Holloway,
Shaolei Lu,
Kamaljeet Singh,
Jovian Yu,
Mary Anne Fenton,
Rachel A. Altura
et al.
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Full-length article
(In Press Corrected Proof)
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07 November 2011 |
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Inhibin-α and synaptophysin immunoreactivity in synovial sarcoma with granular cell features
DOI: 10.1016/j.humpath.2011.07.012
Summary: We recognized immunoreactivity for the α subset of inhibin and synaptophysin in synovial sarcomas with granular cell features. Histologic findings of 90 cases of synovial sarcoma were reviewe...
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Nokitaka Setsu,
Kenichi Kohashi,
Makoto Endo,
Hidetaka Yamamoto,
Yoshihiro Ohishi,
Kazunobu Sueyoshi,
Yukihide Iwamoto,
Masazumi Tsuneyoshi,
Toru Motoi,
Arisa Kumagai,
Yoshinao Oda
et al.
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Full-length article
(In Press Corrected Proof)
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07 November 2011 |
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A distinctive translocation carcinoma of the kidney; “rosette forming,” t(6;11), HMB45-positive renal tumor: a histomorphologic, immunohistochemical, ultrastructural, and molecular genetic study of 4 cases
DOI: 10.1016/j.humpath.2011.07.001
Summary: To date, only a few cases of “rosette forming t(6;11), HMB45-positive renal carcinoma” have been published. In this article, we contribute further data on 4 cases of this rare entity. Patient...
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Fredrik Petersson,
Tomáš Vaněček,
Michal Michal,
Guido Martignoni,
Matteo Brunelli,
Zbyněk Halbhuber,
Dominic Spagnolo,
Naoto Kuroda,
Ximing Yang,
Isabel Alvarado Cabrero,
Milan Hora,
Jindřich Branžovský,
Sandra Trivunic,
Denisa Kacerovská,
Petr Steiner,
Ondřej Hes
et al.
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Full-length article
(In Press Corrected Proof)
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04 November 2011 |
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The presence and location of epithelial implants and implants with epithelial proliferation may predict a higher risk of recurrence in serous borderline ovarian tumors: a clinicopathologic study of 188 cases
DOI: 10.1016/j.humpath.2011.06.023
Summary: Serous borderline ovarian tumors have a favorable prognosis, and recurrences are uncommon. The factors influencing recurrence are not fully understood. Epithelial inclusions are identified in...
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M. Ruhul Quddus,
C. James Sung,
Cunxian Zhang,
Richard G. Moore,
Joyce J. Ou,
Margaret M. Steinhoff,
W. Dwayne Lawrence
et al.
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Full-length article
(In Press Corrected Proof)
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02 November 2011 |
